CFS ME CFIDS Research and medication database. Myalgic Encephalomyelitis. Chronic fatigue and immune dysfunction  syndrome.
Diagnostic markers

Diagnostic markers

There are in fact a good number of scientific markers of abnormalities in ME-CFIDS-CFS!

To all experts - I need your help here!
Please help to create a 'relevancy-hitlist' of all those diagnostic markers.

And please tell me of other, more up-to-date diagnostic markers on the chatbox.


Diagnostic markers for ME-CFIDS-CFS

To all experts!

Please help to create a hitlist of all those diagnostic markers,
beginning with the most significant on top.

If you know other diagnostic markers
(or if some on these list are outdated and/or redundant) please let me know.

Also if you happen to know who is doing active and ongoing studies on these markers or have stopped them, please contact me.
I will incorporate/update them on this list.

investicator (at) hotmail (dot) com

There are a good number of scientific markers of abnormalities in this disease. Here are just some of those:

Spectroscopic diagnosis of Chronic Fatigue Syndrome by visible and near-infrared spectroscopy in serum samples.

Japanese researchers concluded that “Vis-NIR spectroscopy for sera combined with chemometrics analysis could provide a promising tool to objectively diagnose CFS.”

Fatigue Clinical Center in Osaka, Japan
Abnormal brain SPECT & PET scans The Clinical and Scientific Basis of Myalgic Encephalomyelitis/CFS
Dr. Byron Hyde
Mitochondrial encephalopathy Dr. Paul Cheney using Magnetic Resonance Spectroscopy


Abnormal capillary flow due to high percentage of flat red blood cells instead of the normal discoid shaped red blood cells Dr. Les Simpson, rheologist from New Zealand
Reduced red blood cell mass (RBC) a critical hematological marker of ME-CIFDS-CFS.
(University of Miami)
Low circulating blood volume Dr. David Bell, Lyndonville, New York
Abnormal bicycle ergometry test with gas analysis indicating immediate movement to anaerobic threshold in ME-CFIDS patients Dr. Paul Cheney,
who used this test for his disability reports
High percentage of patients with a viral load (HHV-6, EBV, cytomegalovirus) and/or Mycoplasma bacteria Dr. Ablashi, Dr. Knox, Dr. Carrigan, Dr. Nicholson
Cardiac abnormalities due to viral invasion into the heart Dr. Martin Lerner
Disregulated HPA axis Dr. Mark Demitrack, Dr. Anthony Komaroff
Disregulated antiviral pathway Dr. Suhadolnik
RNase L enzyme test Dr. Robert Suhadolnik
Head-up tilt test with haemodynamic instability Dr. J. E. Naschitz
Abnormal T-helper 1/T-helper 2 Function Panel Dr. Paul Cheney
Very low/impaired Natural Killer Cell Function Dr. Paul Cheney, Dr. Kenny Demeirleir
Prolonged vasodilatory effect of acetylcholine on the microvasculature addition to Peripheral Cholinergic illness in ME-CFIDS patients, Gulf War Illness, and illness following Organophosphate Exposure.
(Dr. Vance Spence)
Cardiomyopathy, liver failure, pancreatic cancer, brain tumors & renal disease ...reported after 40 years of research in Enteroviral and Toxin Mediated ME-CFIDS and Other Organ Pathologies.
(Dr. John Richardson)
Positive testing for Ciguatera Toxin Epitope Dr. Yoshitsugi Hokama
(Research funded by the National CFIDS/M.E. Foundation)
Neurally mediated hypotension  
Abnormal “voyager” RNA (Preliminary studie) Dr. Paul Cheney
5-HIAA, a metabolite of serotonin, may be present in elevated levels in ME-CFIDS patients Georgetown University
Concentrations of a glucose metabolite in red blood cells  
Differences in gene expression profiles Dr. William Reeves in the cfids Chronicle
Excess nitric oxide activity  
Blood hypercoagulability  
Subclinical adrenal insufficiency (present in about 2/3's of cases)
Reduced body temperature (can be caused by hypoadrenal +/- hypothyroid)
Magnesium deficiency  
Many thanks so far to the following gentlemen:
Blake Graham from Australia. Check out his very interesting site on nutrition and fatigue/ME-CFIDS-CFS subsite:

Steven Du Pre
isaiah43 (at) lanset (dot) com